SUMO1 Negatively Regulates Reactive Oxygen Species Production From NADPH Oxidases

SUMO1 negatively regulates reactive oxygen species production from NADPH oxidases.

OBJECTIVE Increased protein SUMOylation (small ubiquitin-related modifier [SUMO]) provides protection from cellular stress, including oxidative stress, but the mechanisms involved are incompletely understood. The NADPH oxidases (Nox) are a primary source of reactive oxygen species (ROS) and oxidative stress, and thus our goal was to determine whether SUMO regulates NADPH oxidase activity. MET...

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SUMO1 Negatively Regulates Reactive Oxygen Species Production From NADPH Oxidases

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